PXD044678-1

PXD044678 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Loss of function cancer associated mutations in the EIF4G2 non canonical translation initiation factor
Description	Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediates internal ribosome entry site (IRES) and upstream open reading frame (uORF) dependent initiation mechanisms, which can be used to modulate protein expression in cancer. Here we explored the contribution of EIF4G2 to cancer by screening the COSMIC database for EIF4G2 somatic mutations in cancer patients.
HostingRepository	MassIVE
AnnounceDate	2023-12-20
AnnouncementXML	Submission_2023-12-20_02:00:37.593.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yishai Levin
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Oxidation; Acetyl
Instrument	Q Exactive HF-X; timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-21 01:06:23	ID requested
⏵ 1	2023-12-20 02:00:37	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Cancer, translation initiation, EIF4G2

submitter keyword: Cancer, translation initiation, EIF4G2

Contact List

Adi Kimchi
contact affiliation	Weizmann Institute of Science
contact email	adi.kimchi@weizmann.ac.il
lab head
Yishai Levin
contact affiliation	Weizmann Institute of Science
contact email	yishai.levin@weizmann.ac.il
dataset submitter

Full Dataset Link List

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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000092704/