PXD044648-1

PXD044648 is an original dataset announced via ProteomeXchange.

Title	Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome
Description	Mouse models of Alzheimer’s Disease (AD), which show progression through various AD stages reflective of human pathology, like 5XFAD, are well established tools for uncovering novel AD related pathways. In addition, they permit temporal examination of the intermingling of AD related pathways and can be used to potentially dissect initiating and propagating events in AD, which are critical for developing biomarkers or designing interventions in early stages of the disease. The present research offers global phosphoproteome profilling of a familial AD mice model with a design including variables of: time (three, six, and nine months), genetic background (5XFAD vs. WT), and sex (equal males and females).
HostingRepository	PRIDE
AnnounceDate	2024-10-15
AnnouncementXML	Submission_2024-10-15_01:50:09.614.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD044648
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Filipa Blasco Tavares Pereira Lopes
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-18 08:43:23	ID requested
⏵ 1	2024-10-15 01:50:10	announced
2	2024-10-22 07:01:48	announced	2024-10-22: Updated project metadata.

10.6019/PXD044648;

10.1016/J.ISCI.2024.110941;

submitter keyword: 5XFAD, Hippocampus, Alzheimer's Disease, Phosphoproteome

Mark R. Chance
contact affiliation	Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, USA
contact email	mark.chance@case.edu
lab head
Filipa Blasco Tavares Pereira Lopes
contact affiliation	Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
contact email	Fxb99@case.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD044648

PRIDE project URI

• PRIDE
  1. PXD044648
     1. Label: PRIDE project
     2. Name: Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome