PXD044644 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Neutrophil extracellular traps melt Peyer’s patches following stroke and myocardial infarction |
Description | Sterile tissue injury after stroke causes lymphocyte contraction in lymphoid tissues and may decrease circulating IgA-levels. Intestinal Peyer’s patches (PP) harbor large numbers of IgA+ B cell precursors and plasma cells. Whether and how tissue injury triggers PP-B cell death, thereby mediating IgA-loss, is unknown. We found decreased circulating IgA levels in stroke and myocardial infarction patients. Experimental stroke and myocardial infarction in mice phenocopied the human situation. Decreased plasma and fecal IgA were accompanied by rapid and macroscopic shrinkage of PP caused by substantial losses of PP-resident IgA+ precursors and plasma cells in mice. Tissue injury induced neutrophil activation endowed with the release of toxic neutrophil extracellular traps (NETs). Antibody-mediated or genetically- induced neutrophil loss, digestion of NETs, or inhibition of their release by the Gasdermin D blockade completely prevented lymphocyte loss and PP shrinkage. We also identified NETs in the plasma of stroke and myocardial infarction patients. Hence, tissue injury induces systemic NET-release, which might be targeted to maintain immune homeostasis at mucosal barriers. |
HostingRepository | PRIDE |
AnnounceDate | 2024-02-28 |
AnnouncementXML | Submission_2024-02-28_06:25:00.619.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Susmita Ghosh |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-18 08:36:46 | ID requested | |
⏵ 1 | 2024-02-28 06:25:01 | announced | |
Publication List
Keyword List
submitter keyword: Stroke, neutrophil extracellular traps, immunosuppression, lymphocytes, myocardial infarction, Peyer’s patches |
Contact List
Prof. Dr. Albert Sickmann |
contact affiliation | President Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz |
contact email | albert.sickmann@isas.de |
lab head | |
Susmita Ghosh |
contact affiliation | Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. |
contact email | susmita.ghosh@isas.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD044644 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044644
- Label: PRIDE project
- Name: Neutrophil extracellular traps melt Peyer’s patches following stroke and myocardial infarction