PXD044642-1

PXD044642 is an original dataset announced via ProteomeXchange.

Title	Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
Description	β-hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia (BT), are the most common inherited monogenic blood disorders globally. Despite decades of research, there are only four FDA-approved medications available for the management of SCD with hydroxyurea (HU) being the most widely used drug that partially benefits patients by inducing fetal hemoglobin (HbF) production. On the other hand, there are no approved oral drugs currently available for β-thalassemia patients. To our knowledge, there are currently no well-characterized erythroid progenitor cell lines available that can accurately replicate the pathophysiology of SCD and BT while also having the same genetic background apart from the disease mutation enabling consistency and reproducibility. Our novel, physiologically relevant cellular systems provide a plethora of avenues for researchers to investigate various applications related to parasite invasion, drug validation, and genome-editing in the context of SCD and BT.
HostingRepository	PRIDE
AnnounceDate	2024-02-07
AnnouncementXML	Submission_2024-02-07_01:03:39.254.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sivaprakash Ramalingam
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-18 08:35:52	ID requested
⏵ 1	2024-02-07 01:03:39	announced

Dataset with its publication pending

submitter keyword: proteomics, mass spectrometer, sickle cell disease, Erythroid progenitor line, CRISPR/Cas9, 10-plex TMT label,β-thalassemia

Sivaprakash Ramalingam
contact affiliation	CSIR-Institute of Genomics and Integrative Biology, New Delhi
contact email	sivaramalingam@igib.res.in
lab head
Sivaprakash Ramalingam
contact affiliation	CSIR-Insitute of Genomics and Integrative Biology, New Delhi
contact email	sivaramalingam@igib.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD044642

PRIDE project URI

• PRIDE
  1. PXD044642
     1. Label: PRIDE project
     2. Name: Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies