PXD044636-1

PXD044636 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Hydrogen Deuterium Exchange of PI4K(530-560) Peptide with Calcineurin
Description	we used HDXMS to study if PI4KA(530-560) is able to bind calcineurin. Here we showed a significant protection in deuterium exchange upon binding calcineurin in the wild type state, indicating these proteins are interacting. Using a mutant that should inhibit the interaction (AKASAA), we showed that this mutant does in fact prevent protection by calcineurin.
HostingRepository	PRIDE
AnnounceDate	2024-09-03
AnnouncementXML	Submission_2024-09-03_13:12:08.750.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-18 08:34:08	ID requested
⏵ 1	2024-09-03 13:12:20	announced

Publication List

Shaw AL, Suresh S, Parson MAH, Harris NJ, Jenkins ML, Yip CK, Burke JE, Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A. Structure, ():(2024) [pubmed]
10.1016/j.str.2024.08.007;

Shaw AL, Suresh S, Parson MAH, Harris NJ, Jenkins ML, Yip CK, Burke JE, Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A. Structure, ():(2024) [pubmed]

10.1016/j.str.2024.08.007;

Keyword List

submitter keyword: HDXMS, Pi4k, Calcineurin

submitter keyword: HDXMS, Pi4k, Calcineurin

Contact List

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD044636
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD044636

PRIDE project URI

Repository Record List

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