PXD044617-1

PXD044617 is an original dataset announced via ProteomeXchange.

Title	A framework for the exploration of multifaceted subcellular RNA-binding proteins (IP-MS)
Description	The ability of RNA binding proteins (RBPs) to form complexes with other biomolecules underpins a very broad range of functions and remarkable structural properties. Understanding the precise spatiotemporal dynamics of RBPs and their interacting partners in the steady state and upon perturbation is key to deciphering these aspects. Here, we present the coRIC (compartmentalized RNA Interactome Capture) map, an experimental resource and analytical framework to study the subcellular dynamics of RBPs through multimodal dataset integration and machine learning. Using this approach, we have generated an atlas comprising 1,768 RBPs distributed in a broad panel of subcellular compartments and delineated their intermolecular and intercompartmental relationships. We have also defined the hierarchy of RBP-containing complexes across the cell, uncovering previously unknown functions of multiple RBPs. Furthermore, we have investigated the changes in RBP complex composition and subcellular distribution in response to DNA damage stress and exposure to C9ORF72 amyotrophic lateral sclerosis/frontotemporal dementia dipeptide repeats. The coRIC map provides a valuable new approach for defining the roles of RBPs in homeostasis and disease.
HostingRepository	PRIDE
AnnounceDate	2026-01-31
AnnouncementXML	Submission_2026-01-30_23:16:14.781.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Lv
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-18 05:13:59	ID requested
⏵ 1	2026-01-30 23:16:15	announced

Dataset with its publication pending

submitter keyword: None

Miguel Esteban
contact affiliation	BGI Research
contact email	miguelesteban@genomics.cn
lab head
Yuan Lv
contact affiliation	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
contact email	lv_yuan@gibh.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD044617

PRIDE project URI

• PRIDE
  1. PXD044617
     1. Label: PRIDE project
     2. Name: A framework for the exploration of multifaceted subcellular RNA-binding proteins (IP-MS)