PXD044610-1

PXD044610 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DISTINCT SALIVARY PROTEOMIC PATTERNS AS SIGNATURE FOR MOLAR INCISOR HYPOMINERALIZATION STAGES
Description	Saliva is a rich-bodily fluid with recognized clinical diagnosis roles and this research aimed at investigating if there is any change in the salivary proteome signatures of MIH children with distinct degrees of severity. Fifty schoolers (6-10 years) were equally assigned into the following groups: Group 1 (Control group - Healthy teeth), Group 2 (Mild MIH with white/creamy opacity and free of caries), Group 3 (Mild MIH with yellow/brown opacity and free of caries), Group 4 (Severe MIH with white/creamy, yellow/brown opacities including post-eruptive fracture and free of caries), Group 5 (Severe MIH with white/creamy, yellow/brown opacities, post-eruptive fracture, and caries). Unstimulated saliva samples were collected and later explored using mass spectrometry analysis. In total, 6,471 proteins were found, 5,073 exclusively from MIH children, and 778 overlapping among the different degrees of the disturb. The Biological Pathways displayed distinct patterns among the groups, being different according to the degrees of MIH. Gene-Odontology differences might not be verified regarding the biological processes and cellular components. Conversely, with respect to molecular function, alterations among groups were evident, with the presence of proteins that would contribute to MIH in children with the severe condition (i.e, calcium ion binding, microtubule binding, platelet-derived growth factor binding). In conclusion, the results of this study support important salivary proteomic changes in MIH children, according to distinct degrees of severity, reinforcing the interplay between the clinical aspects of hypomineralization (white/yellow opacities/enamel breakdown) and changes in the salivary proteome.
HostingRepository	jPOST
AnnounceDate	2024-08-18
AnnouncementXML	Submission_2024-08-17_08:00:05.935.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thais
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	Xevo G2-XS QTof

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-17 13:42:17	ID requested
⏵ 1	2024-08-17 08:00:06	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Dental hypomineralization. Salivary proteins

submitter keyword: Dental hypomineralization. Salivary proteins

Contact List

Thais Manzano Parisotto
lab head
Thais
contact affiliation	Universidade São Francisco
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002289/