PXD044505 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of skeletal muscle fibre samples from hibernating and awake bears |
Description | Recent discoveries in the field of skeletal muscle have found that the contractile protein myosin is able to dictate the resting metabolic rate of this organ. In this study we aimed to investigate if myosin is involved in the process of metabolic shutdown which is observed during hibernation. We found that in small hibernating mammals, the rate of ATP turnover dictated by myosin was altered and that this was also dependent upon the temperature of skeletal muscle. We further investigated changes to the whole proteome of these animals and observed that in small hibernators found significant changes to sarcomere organization during hibernating periods. Finally, we identified hyperphosphorylation upon the myosin molecule in these small hibernators which was predicted to induce stability changes to this molecule. |
HostingRepository | PRIDE |
AnnounceDate | 2024-04-29 |
AnnouncementXML | Submission_2024-04-29_02:47:48.378.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Wierer |
SpeciesList | scientific name: Ursus arctos arctos (European brown bear); NCBI TaxID: 563924; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-11 04:50:18 | ID requested | |
⏵ 1 | 2024-04-29 02:47:48 | announced | |
Publication List
Keyword List
submitter keyword: uscle, Myosin, Hibernation |
Contact List
Julien Ochala |
contact affiliation | University of Copenhagen Department of Biomedical Sciences Blegdamsvej 3B København N, DK-2200 |
contact email | julien.ochala@sund.ku.dk |
lab head | |
Michael Wierer |
contact affiliation | Proteomics Research Infrastructure, University of Copenhagen |
contact email | michael.wierer@sund.ku.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD044505 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044505
- Label: PRIDE project
- Name: Proteomic analysis of skeletal muscle fibre samples from hibernating and awake bears