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PXD044438-1

PXD044438 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSkin proteomics reveals the potential mechanism of AgNCs-hydrogel in promoting the regeneration of diabetic infectious wounds
DescriptionDiabetic infectious wounds treatment is challenging due to insistent wound infections. Treating such complicated pathological diabetic infectious wounds needs to develop multifunctional materials and understand their mechanism. Here, we developed a novel material termed AgNCs-hydrogel, which is a multifunctional DNA hydrogel which dressing by integrating antibacterial silver nanoclusters. AgNCs-hydrogel was used for promoting the regeneration of diabetic infectious wounds in mouses because that it exhibited superior antibacterial activity, satisfactory biocompatibility, and effective ROS-scavenging property. Based on the skin proteomics, we explored the potential mechanism of AgNCs-hydrogel in treating mouse skin wounds. We found that AgNCs-hydrogel can accelerate proliferation and extracellular matrix (ECM) formation. In proteomic level, AgNCs-hydrogel can regulate some key proteins which mainly located in the extracellular exosome, involved in negative regulation of apoptotic process, performed ATP binding for accelerating diabetic infected wound closure. Therefore, this study provided a multifunctional material AgNCs-hydrogel and revealed its potential mechanisms in promoting the regeneration of diabetic infectious wounds.
HostingRepositoryiProX
AnnounceDate2023-08-07
AnnouncementXMLSubmission_2023-08-08_02:01:24.134.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYong Zhang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-08 02:01:00ID requested
12023-08-08 02:01:24announced
22024-05-22 20:03:15announced2024-05-23: Update information.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Silver nanoclusters, DNA hydrogel, Skin proteomics, Diabetic wound healing
Contact List
Yong Zhang
contact affiliationWest China Hospital, Sichuan University
contact emailnankai1989@foxmail.com
lab head
Yong Zhang
contact affiliationWest China Hospital, Sichuan University
contact emailnankai1989@foxmail.com
dataset submitter
Full Dataset Link List
iProX dataset URI