PXD044432-2

PXD044432 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomics analysis of bladder cancer tissues to reveal proteins associated with cancer progression
Description	The project aimed to determine proteomics changes in Bladder cancer (BCa) tissue from early to more advanced stages of the disease and identify the proteins associated with the progression. The samples used in this study were fresh frozen BCa tissues from patients collected immediately after surgery, with histopathologicaly confirmed disease. Samples were grouped according to the histopathological report in 3 groups: 1) Group 1 (pTa, G1), 2) Group 2 (T1, G2-G3) and 3) Group 3 (pT2-T3, G3). Patients were aged 28–82 years with no significant differences among groups regarding age: Median age (Group 1 (pTa, G1)) =62; Median age (Group 2 (T1, G2-G3)) =58 and Median age (Group 3 (pT2-T3, G3)) =73.5. Each group had 6 samples or 18 samples in total were used for the comparative proteomics analysis by label-free data-independent LC-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:09.036.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD044432
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Katarina Davalieva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-08 00:54:17	ID requested
1	2023-10-22 14:57:40	announced
⏵ 2	2023-11-14 09:06:15	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:06:57	announced	2024-10-22: Updated project metadata.

10.6019/PXD044432;

Davalieva K, Kiprijanovska S, Ivanovski O, Trifunovski A, Saidi S, Dimovski A, Popov Z, Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa. Int J Mol Sci, 24(19):(2023) [pubmed]

submitter keyword: Human, fresh frozen tissues, bladder cancer, Rapigest, Progenesis QIP, LC-MS/MS

Katarina Davalieva,
contact affiliation	Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Krste Misirkov 2, 1000 Skopje, Republic of North Macedonia Tel.: +389-2-3235-410; Fax: +389-2-3115-434
contact email	katarina@manu.edu.mk
lab head
Katarina Davalieva
contact affiliation	Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje
contact email	katarina@manu.edu.mk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD044432

PRIDE project URI

• PRIDE
  1. PXD044432
     1. Label: PRIDE project
     2. Name: Comparative proteomics analysis of bladder cancer tissues to reveal proteins associated with cancer progression