PXD044405-1

PXD044405 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation
Description	Chemical cross-linking coupled to mass spectrometry was used to study the interaction between IgG-type antibodies and the neonatal Fc receptor (FcRn). Different cross-linking chemistries were used, including disuccinimidyl suberate (DSS); a combination of pimelic dihydrazide (PDH) in combination with the zero-length cross-linking reagent, DMTMM; and the Xplex method using hexanediamine and N-hydroxybenzotriazole.
HostingRepository	PRIDE
AnnounceDate	2024-12-03
AnnouncementXML	Submission_2024-12-03_01:41:24.261.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Leitner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-07 01:21:12	ID requested
⏵ 1	2024-12-03 01:41:24	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Chemical cross-linking
DSS
PDH
DMTMM
XPlex
structural proteomics
antibody – receptor interactions

submitter keyword: Chemical cross-linking

DSS

PDH

DMTMM

XPlex

structural proteomics

antibody – receptor interactions

Contact List

Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology, Zurich, Switzerland
contact email	leitner@imsb.biol.ethz.ch
lab head
Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD044405
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD044405

PRIDE project URI

Repository Record List

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