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PXD044308-1

PXD044308 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman astrocyte secretome data
DescriptionIn late-onset sporadic Alzheimer’s disease (AD), the most prevalent and strongest risk factor is the ε4 allele of the apolipoprotein E (APOE4). To investigate the pathophysiological effects of the APOE4 genotype in the human cellular context, we generated isogenic iPSC-derived astrocytes bearing APOE4 alleles from APOE3 control iPSC. Next, to identify astrocytic APOE4-specific secreted proteomes, we performed a mass spectrometry using culture media from human astrocytes carrying APOE3 or APOE4.
HostingRepositoryjPOST
AnnounceDate2023-09-01
AnnouncementXMLSubmission_2023-08-31_21:54:49.018.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHirotaka Watanabe
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; Acetyl; L-methionine sulfoxide
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-02 19:37:04ID requested
12023-08-31 21:54:49announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, Astrocyte
Contact List
Hideyuki Okano
lab head
Hirotaka Watanabe
contact affiliationKeio University
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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