PXD044277 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interactome analysis of PHF2 using LC-MS combined with an immunoprecipitation assay |
Description | PHF2 demethylates lysine 9 in histone 3 and acts as a tumor suppressor. In liver pathogenesis, PHF2 has dual effects. PHF2 induces simple hepato-steatosis by epigenetically coactivating ChREBP. When lipid accumulation goes serious, it protects the liver from fibrogenesis by facilitating Nrf2 activity, a major transcription factor in the defense against oxidative stress during non-alcoholic fatty liver disease. However, little is known regarding the functions of PHF2 in liver cancer cells. Therefore, to investigate the possible roles of PHF2 and find new interacting proteins, we performed an LC-MS/MS assay combined with an immunoprecipitation assay. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-18 |
AnnouncementXML | Submission_2023-10-17_16:40:00.119.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Do-WonJeong |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-01 19:40:10 | ID requested | |
⏵ 1 | 2023-10-17 16:40:00 | announced | |
2 | 2023-11-14 07:52:30 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: LC-MSMS,PHF2, Hepatocellular carcinoma, HepG2 |
Contact List
Yang-SookChun |
contact affiliation | Seoul National University College of Medicine |
contact email | chunys@snu.ac.kr |
lab head | |
Do-WonJeong |
contact affiliation | Seoul National University College of Medicine |
contact email | do123@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044277
- Label: PRIDE project
- Name: Interactome analysis of PHF2 using LC-MS combined with an immunoprecipitation assay