PXD044134-1

PXD044134 is an original dataset announced via ProteomeXchange.

Title	Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Description	Polycystic ovary syndrome (PCOS) is a heterogeneous condition, of polyhedric pathogenesis and clinical presentation, defined by oligo-/anovulation, hyperandrogenism and/or polycystic ovaries. Metabolic complications are highly common also in patients suffering PCOS, including obesity, insulin resistance and type-2 diabetes, which severely compromise the clinical course of affected women. Yet, therapeutic options for PCOS remain mostly symptomatic and of limited efficacy for improving both metabolic and reproductive alterations. We report herein the hormonal, metabolic and gonadal responses to different GLP1-based multi-agonists, namely GLP1/Estrogen (GLP1/E), GLP1/GIP and GLP1/GIP/Glucagon, in two murine models of PCOS, with variable penetrance of metabolic and reproductive traits, and their comparison with metformin. Our data illustrate the superior efficacy of the di-agonist, GLP1/E, vs. other multi-agonists and metformin in the management of the metabolic complications of PCOS; GLP1/E was able to ameliorate also ovarian cyclicity in an ovulatory model of PCOS, without direct estrogenic uterotrophic effects. In keeping with GLP1-mediated brain targeting, label-free, quantitative proteomics revealed changes in common and distinct hypothalamic pathways in response to GLP1/E between the two PCOS models, as basis for differential efficiency. Altogether, our data set the basis for the use of GLP1-based multi-agonists, and particularly GLP1/E, in the personalized management of PCOS.
HostingRepository	PRIDE
AnnounceDate	2024-10-02
AnnouncementXML	Submission_2024-10-02_07:07:20.650.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Víctor Serrano López
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-27 03:27:00	ID requested
⏵ 1	2024-10-02 07:07:21	announced

S, á, nchez-Garrido MA, Serrano-L, ó, pez V, Ruiz-Pino F, V, á, zquez MJ, Rodr, í, guez-Mart, í, n A, Torres E, Velasco I, Rodr, í, guez AB, Chicano-G, á, lvez E, Mora-Ortiz M, Ohlsson C, Poutanen M, Pinilla L, Gayt, á, n F, Douros JD, Yang B, M, ü, ller TD, DiMarchi RD, Tsch, ö, p MH, Finan B, Tena-Sempere M, Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy. Nat Commun, 15(1):8498(2024) [pubmed]

10.1038/s41467-024-52898-y;

submitter keyword: PCOS, GLP1, GLP1/GIP, GLP1/GIP/Glucagon, GLP1/E

Manuel Tena Sempere
contact affiliation	Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba. Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba. Hospital Universitario Reina Sofía, Córdoba, Spain. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, Spain.
contact email	fi1tesem@uco.es
lab head
Víctor Serrano López
contact affiliation	Universidad de Córdoba
contact email	b02selov@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD044134

PRIDE project URI

• PRIDE
  1. PXD044134
     1. Label: PRIDE project
     2. Name: Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy