PXD044074-1

PXD044074 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial MOF regulates energy metabolism in heart failure by ATP5B hyperacetylation
Description	In current study, we found that the protein level of MOF in mitochondrial was significantly increased during the course of heart failure. Overexpression of mtMOF induced cardiac hypertrophy and energy metabolism disorder, as well as heart failure. When combined with mtMOF overexpression and SIRT3 deficiency, the acetylation level in cardiomyocytes was significantly upregulated, accompanied with serious enegergy abnormal and cardiac function injury. Mitochondrial substrates of MOF was identified by using acetylated proteomic analysis. We demonstrated that mtMOF and SIRT3 exhibited damage effect by regulating the acetylation level of the common substrate ATP5B. This study clarified the acetyltransferase activity of MOF in mitochondria, providing a new theoretical basis for the acetylation regulation mode of mitochondrial proteins. In addition, we provides a new research idea for exploring the relationship between hyperacetylation and energy metabolism disorder and heart failure.
HostingRepository	PRIDE
AnnounceDate	2024-12-09
AnnouncementXML	Submission_2024-12-09_07:34:46.876.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	YUYU YOU
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-25 08:53:00	ID requested
⏵ 1	2024-12-09 07:34:47	announced

Dataset with its publication pending

submitter keyword: acetylation,MOF, energy metabolism, heart failure, ATP5B

Mao Yang
contact affiliation	Sun Yat-sen University
contact email	maoyang3@mail.sysu.edu.cn
lab head
YUYU YOU
contact affiliation	SYSU
contact email	youyy8@mail.sysu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044074
     1. Label: PRIDE project
     2. Name: Mitochondrial MOF regulates energy metabolism in heart failure by ATP5B hyperacetylation