PXD043964-1

PXD043964 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Luminal cerebrovascular proteomic changes during aging
Description	The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis. However, during aging and neurodegenerative disease, the BBB undergoes numerous molecular changes that can promote inflammation and disease pathogenesis. In this work, we profile the luminal (blood-facing) surface of the cerebral vasculature using sulfo-NHS-biotin to tag and enrich proteins from acutely isolate microvessedls from young (3-month-old) and aged (21-month-old) mice.
HostingRepository	PRIDE
AnnounceDate	2024-12-17
AnnouncementXML	Submission_2024-12-17_09:45:10.593.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sophia Shi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-20 12:44:55	ID requested
⏵ 1	2024-12-17 09:45:10	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: brain,Mouse, vasculature, BBB, aging

submitter keyword: brain,Mouse, vasculature, BBB, aging

Contact List

Tony Wyss-Coray
contact affiliation	Department of Neurology and Neurological Sciences, Stanford University
contact email	twc@stanford.edu
lab head
Sophia Shi
contact affiliation	Stanford University
contact email	smshi@stanford.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD043964
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD043964

PRIDE project URI

Repository Record List

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