PXD043908-1

PXD043908 is an original dataset announced via ProteomeXchange.

Title	A T-cell receptor targeting a shared neoantigen mediates elimination of primary human acute myeloid leukemia in vivo
Description	This paper presents a T-cell receptor (TCR) reactive to the recurrent D835Y driver mutation in the FLT3 tyrosine-kinase domain. TCRFLT3D/Y-redirected T cells selectively eliminated primary human AML cells harboring the D835Y mutation in vitro and in vivo. The TCRFLT3D/Y cells rejected both CD34+ and CD34- AML in mice engrafted with primary leukemia from patients, reaching minimal residual disease negative levels, and eliminated primary CD34+ AML leukemia-propagating cells in vivo. Thus, T cells targeting a single shared mutation can provide efficient immunotherapy towards selective elimination of clonally involved primary AML cells in vivo.
HostingRepository	PRIDE
AnnounceDate	2023-08-28
AnnouncementXML	Submission_2023-08-28_00:37:30.904.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ravi ChandBollineni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-19 05:26:52	ID requested
⏵ 1	2023-08-28 00:37:31	announced

Dataset with its publication pending

submitter keyword: Human, PRM, LC-MS, acute myeloid leukemia, cellular immunotherapy

JohannaOlweus
contact affiliation	Head, Dept of Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Ullernchausséen 70, 0379 Oslo, Norway
contact email	johanna.olweus@medisin.uio.no
lab head
Ravi ChandBollineni
contact affiliation	University of Oslo
contact email	r.c.bollineni@ibv.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD043908

PRIDE project URI

• PRIDE
  1. PXD043908
     1. Label: PRIDE project
     2. Name: A T-cell receptor targeting a shared neoantigen mediates elimination of primary human acute myeloid leukemia in vivo