PXD043872 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic dissection of Vanishing white matter pathogenesis |
Description | We aimed at gaining more insight into the molecular basis of VWM pathogenesis. Therefore we investigated protein expression patterns in the 2b5ho mouse model using a data-independent mass spectrometry-based quantitative proteomic analysis. The proteome of 4 different brain regions was analyzed at different time points of disease progression. Brain regions were selected based on their regional vulnerability to VWM, and included the cerebellum, corpus callosum, cortex, and brainstem. Commonalities and differences in proteome changes between 2b5ho mouse and VWM patient brains were assessed to determine disease-relevant protein changes during disease development and progression. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-16 |
AnnouncementXML | Submission_2024-06-16_10:09:10.019.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Peter Robert Mosen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized amino-terminal residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-18 11:44:02 | ID requested | |
⏵ 1 | 2024-06-16 10:09:10 | announced | |
Publication List
Man JHK, Zarekiani P, Mosen P, de Kok M, Debets DO, Breur M, Altelaar M, van der Knaap MS, Bugiani M, Proteomic dissection of vanishing white matter pathogenesis. Cell Mol Life Sci, 81(1):234(2024) [pubmed] |
10.1007/s00018-024-05258-4; |
Keyword List
submitter keyword: Quantitative proteomics, Brain, Leukodystrophy,Vanishing white matter, Disease progression |
Contact List
Marianna Bugiani |
contact affiliation | Department of Pathology, Amsterdam UMC, Vrije UniversiteitAmsterdam, Amsterdam, The Netherlands |
contact email | m.bugiani@amsterdamumc.nl |
lab head | |
Peter Robert Mosen |
contact affiliation | Utrecht University Biomolecular Mass Spectrometry and Proteomics Padualaan 8, 3584 CH Utrecht |
contact email | p.r.mosen@uu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043872 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043872
- Label: PRIDE project
- Name: Proteomic dissection of Vanishing white matter pathogenesis