PXD043860 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nuclear hormone-sensitive lipase controls adipocyte function |
| Description | Hormone-sensitive lipase (HSL) is a neutral lipase which hydrolyses fat stored as triacylglycerols in adipocyte lipid droplets. Its activity is under the control of hormones and neurotransmitters through protein kinase (PK)-mediated phosphorylation. Here we show that HSL is expressed in the nucleus where it controls the biological functions of the adipocyte. Gene editing reveals that the development of adipose tissue in vivo relies on nuclear HSL. In the nucleus, HSL interacts with a network of proteins involved in transcriptional and post-transcriptional events. TGFβ activation of SMAD3 promotes HSL nuclear accumulation whereas PKA-mediated phosphorylation induces HSL nuclear export. HSL nuclear content is increased in obese mouse adipose tissue whereas expression of a catalytically inactive nuclear HSL impairs glucose homeostasis. These findings reveal that nuclear HSL is essential for the maintenance of adipocyte function. HSL integrates signals from the TGFβ and catecholamine signaling pathways and controls adipocyte mitochondrial oxidative activity. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-30 |
| AnnouncementXML | Submission_2026-01-30_01:23:26.371.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Karima Chaoui |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-07-18 00:17:46 | ID requested | |
| ⏵ 1 | 2026-01-30 01:23:26 | announced | |
Publication List
Keyword List
| submitter keyword: obesity, adipocyte,hormone-sensitive lipase, protein-protein interaction, adipose tissue |
Contact List
| Dominique Langin |
|---|
| contact affiliation | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Toulouse III - Paul Sabatier (UPS), Université de Toulouse, UMR1297, Toulouse, France |
| contact email | chaoui@ipbs.fr |
| lab head | |
| Karima Chaoui |
|---|
| contact affiliation | IPBS/CNRS |
| contact email | karima.chaoui@ipbs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD043860 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043860
- Label: PRIDE project
- Name: Nuclear hormone-sensitive lipase controls adipocyte function
