PXD043818 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Defining neutralization and allostery by antibodies against COVID-19 variants |
Description | This project is aimed at characterizing the interactions of SARS-CoV-2 Spike protein and its variants with multiple full-length antibodies and monitoring the accompanying conformational dynamics. Different categories of antibodies are tested that recognize different domains of the Spike protein. The project aims at identifying the effects of weak, moderate and strong neutralizing antibodies on Spike protein and decipher their mechanisms of action. In addition to the direct binding effects, distal allosteric effects are also determined. A range of biophysical experiments, biochemical assays, and molecular dynamics simulations are used as orthogonal approaches. The rationale is to identify regions on the SARS-CoV-2 Spike protein that acts as indicators for antibody binding and use these hotspots to develop better neutralizing antibodies against SARS-CoV-2 and any future viral pandemics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:05:22.188.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nikhil Kumar Tulsian |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-16 17:04:19 | ID requested | |
1 | 2023-10-09 12:33:27 | announced | |
⏵ 2 | 2024-10-22 06:05:22 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Antibodies (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: antibody, epitope-paratope mapping,SARS-CoV-2, HDXMS, neutralization, MD simulations, variants of concern, Spike protein |
Contact List
Paul MacAry |
contact affiliation | Department of Microbiology & Immunology, National University of Singapore, Singapore |
contact email | micpam@nus.edu.sg |
lab head | |
Nikhil Kumar Tulsian |
contact affiliation | Senior Scientist, MSD International GmBH (Singapore) |
contact email | nikhilkt.science@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD043818 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043818
- Label: PRIDE project
- Name: Defining neutralization and allostery by antibodies against COVID-19 variants