PXD043748-2

PXD043748 is an original dataset announced via ProteomeXchange.

Title	Characterization of ZIC4 role in choroid plexus carcinoma
Description	ZIC4 is a transcription factor related to pathways like NOTCH and Sonic Hedgehog (Shh) pathways which are involved in choroid plexus carcinoma (CPC). The current study describes the effect of ZIC4 gene re-expression on a CPC cell line proteome. We performed SILAC-based proteomics of ZIC4-transfected cells versus control cells, as well as empty vector-transfected cells versus control cells. Re-expression of ZIC4 may lead to a better understanding of global gene regulation and identify its role in CPC pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:51:32.945.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dina Hesham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-13 03:24:43	ID requested
1	2024-07-26 02:29:39	announced
⏵ 2	2024-10-22 06:51:33	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: LC-MSMS, CCHE-45, choroid plexus carcinoma, SILAC,ZIC4

Shahenda El-Naggar
contact affiliation	Tumor Biology Research Program, Basic Research Unit, Research Department, Children’s Cancer Hospital in Egypt 57357, Cairo, Egypt
contact email	shahenda.elnaggar@57357.org
lab head
Dina Hesham
contact affiliation	Children's Cancer Hospital 57357 Egypt
contact email	dina.hesham139@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD043748

PRIDE project URI

• PRIDE
  1. PXD043748
     1. Label: PRIDE project
     2. Name: Characterization of ZIC4 role in choroid plexus carcinoma