PXD043607-1

PXD043607 is an original dataset announced via ProteomeXchange.

Title	Supersulphide airway protection in viral and chronic lung diseases
Description	Supersulphides (inorganic and organic sulphides with sulphur catenation) manifest diverse physiological functions. These supersulphides are mainly generated from mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here we found powerful protective functions of supersulphides in viral airway infections (influenza and COVID-19) and chronic lung diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and aged lungs. Enhanced supersulphide exhalation also occurred from human airways in COVID-19 as well as the hamster model of SARS-CoV-2 infection, as identified by breath supersulphur-omics that we developed herein. The lung damage related to oxidative stress and inflammation in mouse models of COPD, IPF, and ageing and the lethal effects that resulted were mitigated by endogenous supersulphides, supplied via CARS2/CPERS or exogenously by the supersulphide donor glutathione trisulphide. Our findings thus elucidated the airway protective role of supersulphides and their therapeutic potential in viral and chronic lung diseases.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:16:52.504.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Seiryo Ogata
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	iodoacetamide derivatized residue
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-07 08:59:08	ID requested
⏵ 1	2024-10-08 11:16:52	announced

Dataset with its publication pending

submitter keyword: 3CLpro,PLpro, spike protein

Takaaki Akaike
contact affiliation	Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
contact email	takaike@med.tohoku.ac.jp
lab head
Seiryo Ogata
contact affiliation	Tohoku University
contact email	sogata@med.tohoku.ac.jp
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043607
     1. Label: PRIDE project
     2. Name: Supersulphide airway protection in viral and chronic lung diseases