PXD043588 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner |
Description | Iron deficiency (ID) is common during gestation and in early infancy and can alter developmental trajectories with lasting consequences on cardiovascular health. While the effects of ID and anemia on the mature heart are well documented, comparatively little is known about their effects and mechanisms on offspring cardiac development and function in the neonatal period. Female Sprague-Dawley rats were fed an iron-restricted or iron-replete diet before and during pregnancy. Cardiac function was assessed in a cohort of offspring on postnatal days (PD) 4, 14, and 28 by echocardiography; a separate cohort was euthanized for tissue collection and hearts underwent quantitative shotgun proteomic analysis. ID reduced body weight and increased relative heart weights at all time points assessed, despite recovering from anemia by PD28. Echocardiographic studies revealed unique functional impairments in ID male and female offspring, characterized by greater systolic dysfunction in the former and greater diastolic dysfunction in the latter. Proteomic analysis revealed down-regulation of structural components by ID, as well as enriched cellular responses to stress; in general, these effects were more pronounced in males. ID causes functional changes in the neonatal heart, which may reflect an inadequate or maladaptive compensation to anemia. This identifies systolic and diastolic dysfunction as comorbidities to perinatal ID anemia which may have important implications for both the short- and long-term cardiac health of newborn babies. Furthermore, therapies which improve cardiac output may mitigate the effects of ID on organ development. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-03 |
AnnouncementXML | Submission_2024-10-03_13:39:52.492.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luiz Gustavo de Almeida |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-06 17:16:00 | ID requested | |
⏵ 1 | 2024-10-03 13:39:52 | announced | |
2 | 2024-10-22 07:00:39 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Nutrition,Anemia, Hypoxia |
Contact List
Antoine Dufour |
contact affiliation | Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada |
contact email | antoine.dufour@ucalgary.ca |
lab head | |
Luiz Gustavo de Almeida |
contact affiliation | University of Calgary |
contact email | luizgustavo.biotec@hotmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043588
- Label: PRIDE project
- Name: Perinatal iron restriction is associated with changes in neonatal cardiac function and structure in a sex-dependent manner