PXD043546-1

PXD043546 is an original dataset announced via ProteomeXchange.

Title	Crosstalk between pentraxin-3 and humoral pattern-recognition receptors plays an essential role in immunomodulation against Aspergillus fumigatus
Description	The study investigated the interaction between pentraxin-3 (PTX3), a soluble pattern-recognition receptor, and the fungal pathogen Aspergillus fumigatus. The aim was to identify the ligands for PTX3 and the impact of PTX3 on the immune response. A. fumigatus spores, hyphae or cell wall components were incubated with PTX3, human serum and others humoral factors and their interaction was studied by immunofluorescence, flow cytometry and ELISA. Opsonizd conidia were co-incubated with human monocyte-derived macrophages (hMDM) and cytokine secretion was measured.
HostingRepository	PRIDE
AnnounceDate	2024-08-02
AnnouncementXML	Submission_2024-08-02_08:21:02.936.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Krüger
SpeciesList	scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: 746128;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-05 01:59:40	ID requested
⏵ 1	2024-08-02 08:21:03	announced

10.1038/S41467-024-51047-9;

submitter keyword: humoral immunity, surfactant protein D,Aspergillus fumigatus, pentraxin-3, C1q, C3b

Axel A. Brakhage
contact affiliation	Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena (Leibniz-HKI)
contact email	axel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliation	Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact email	thomas.krueger@leibniz-hki.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043546
     1. Label: PRIDE project
     2. Name: Crosstalk between pentraxin-3 and humoral pattern-recognition receptors plays an essential role in immunomodulation against Aspergillus fumigatus