PXD043470-1

PXD043470 is an original dataset announced via ProteomeXchange.

Title	The role of endothelial cell-derived extracellular vesicles in acute respiratory distress syndrome
Description	Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life-threatening critical syndrome with no effective pharmacotherapy. Extracellular vesicles (EVs) are considered as a new way of long-distance communication between cells. Our previous research using an ex vivo perfused human ALI model suggested that endothelial cell-derived EVs (EC-EVs) mediate the development of ALI/ARDS. However, how EC-EVs aggravate lung injury remains largely unknown. Here we demonstrated that EC-EVs released under inflammatory stimulation can lead to ALI, and the proteomic analysis was performed on EC-EVs to explore the mechanism.
HostingRepository	iProX
AnnounceDate	2023-07-03
AnnouncementXML	Submission_2026-06-28_18:48:08.275.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lu Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-03 01:53:22	ID requested
⏵ 1	2026-06-28 18:48:08	announced

Dataset with its publication pending

submitter keyword: extracellular vesicles, proteome, endothelial cell

Haibo Qiu
contact affiliation	Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China
contact email	haiboq2000@163.com
lab head
Lu Wang
contact affiliation	Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China
contact email	wangluu0531@163.com
dataset submitter

iProX dataset URI