PXD043448-1

PXD043448 is an original dataset announced via ProteomeXchange.

Title	Reward System Activation Improves Recovery from Acute Myocardial Infarction".
Description	The recovery from acute myocardial infarction (AMI) is influenced by physiological and psychological factors. While the physiological effects have been extensively studied, the contribution of psychological factors and whether they can be modulated is not completely clear. Here we show that the activity of the reward system, a brain network involved in motivation and positive expectation, affects outcomes in mice following AMI. We found that chemogenetic activation of dopaminergic neurons in the ventral tegmental area (VTA) significantly attenuated the remodeling process following AMI, resulting in improved left-ventricular performance compared to controls. VTA activation was associated with modulation of the immune response following AMI and increased blood vessel formation in the damaged area, mediated, at least in part, by changes in liver-secreted proteins. Together, our findings reveal a potential mechanism by which specific brain activity can affect the multifactorial systemic and local tissue response to AMI, introducing a novel target for therapeutic interventions
HostingRepository	PRIDE
AnnounceDate	2024-05-03
AnnouncementXML	Submission_2024-05-03_00:20:36.876.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-02 06:37:22	ID requested
⏵ 1	2024-05-03 00:20:37	announced
2	2024-10-22 06:38:01	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Reward System,myocardial infarction

Asya Rolls
contact affiliation	Rappaport Faculty of Medicine Technion, Israel Institute of Technology, Haifa, Israel
contact email	rolls.asya@gmail.com
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD043448

PRIDE project URI

• PRIDE
  1. PXD043448
     1. Label: PRIDE project
     2. Name: Reward System Activation Improves Recovery from Acute Myocardial Infarction".