PXD043414-1
PXD043414 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Unbiased phosphoproteomics analysis of human myotubes unveils extramitotic CDK1 kinase activity modulates insulin signaling |
Description | We performed total proteome and phosphoproteome analysis to characterize the role of non-mitotic kinase activity of CDK1 in insulin signaling through pharmacological inhibition and translational repression via siRNA-based knockdown. Specifically, cultured myotubes were treated with RO-3306, a selective ATP competitive inhibitor to inhibit CDK1 activity, or transfected with a CDK1 targeting siRNA pool to decrease CDK1 expression. |
HostingRepository | jPOST |
AnnounceDate | 2024-07-04 |
AnnouncementXML | Submission_2024-07-03_08:00:08.158.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD043414 |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Radoslaw Sobota |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; deamidated L-asparagine; deamidated L-glutamine |
Instrument | instrument |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-06-29 23:45:32 | ID requested | |
⏵ 1 | 2024-07-03 08:00:08 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: human, myotube, insulin, phosphoproteomics |
Contact List
E Shyong Tai | |
---|---|
lab head | |
Radoslaw Sobota | |
contact affiliation | IMCB A-STAR Singapore |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002220/ |