PXD043291 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dissecting ubiquitylation and DNA damage response pathways in the yeast Saccharomyces cerevisiae using a proteome-wide approach |
Description | The proper function of DNA damage response pathways (DDR) is essential to protect eukaryotic cells from the accumulation of DNA damage and genome instability, a major cause of cancer and other diseases in humans. Ubiquitylation orchestrates the regulation of DDR events.Blaszczak et al. use quantitative proteomics and a reporter system based on the NanoLuc luciferase to study ubiquitylation and protein abundance changes upon genotoxic stress in yeast. The authors point out proteins that may be regulated by ubiquitylation during the DDR. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-08 |
AnnouncementXML | Submission_2024-10-08_11:15:14.802.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD043291 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Ewa Blaszczak |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | 6x(13)C labeled residue |
Instrument | 6220 Time-of-Flight LC/MS; MALDI Synapt MS; Synapt MS; Q Exactive HF; LCQ Classic; TripleTOF 5600; 6410 Triple Quadrupole LC/MS; Q Exactive; LTQ Orbitrap; 4800 Proteomics Analyzer; 6340 Ion Trap LC/MS; Orbitrap Fusion Lumos; LTQ; LTQ Orbitrap Velos; Q TRAP; Q-Tof Ultima; maXis; LTQ FT; autoflex; ultraflex; QSTAR; 4700 Proteomics Analyzer; Orbitrap Fusion; 6520A Quadrupole Time-of-Flight LC/MS; LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-26 01:46:48 | ID requested | |
⏵ 1 | 2024-10-08 11:15:15 | announced | |
Publication List
Keyword List
submitter keyword: ubiquitylation, IMAC, NanoLuc, qunatitative proteomics, anchor-away, degradation, SILAC, proteasome, MMS, genotoxic stress,ubiquitin, DNA damage response |
Contact List
Ewa Blaszczak |
contact affiliation | Department of Biochemistry and Molecular Biology, Faculty of Medical Sciences, Medical University of Lublin |
contact email | ewa.blaszczak1@umlub.pl |
lab head | |
Ewa Blaszczak |
contact affiliation | Department of Biochemistry and Molecular Biology, Faculty of Medical Sciences, Medical University of Lublin |
contact email | ewa.blaszczak1@umlub.pl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043291
- Label: PRIDE project
- Name: Dissecting ubiquitylation and DNA damage response pathways in the yeast Saccharomyces cerevisiae using a proteome-wide approach