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PXD043256-1

PXD043256 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteomics analysis of Salmonella-infected mouse cecum
DescriptionThe ECM is a complex fibrillar network of macromolecules that provides structural and mechanical support to the intestinal tissue. One abundant component of the ECM observed in the Salmonella-driven intestinal edema is the mechanosensitive glycoprotein fibronectin. Combining mechanosensitive staining for relaxed fibronectin with total fibronectin revealed that fibronectin fibers present in the edema are in a tensed molecular conformation. Co-staining with fibrin(ogen) indicates a provisional matrix, similar to what is observed in response to skin injury. The absence of low tensional fibronectin fibers and the additional finding of a high number of protease inhibitors in the edema proteome could indicate a critical role of stretched fibronectin fibers in maintaining tissue integrity in the severely inflamed cecum. Understanding these processes may provide valuable functional diagnostic markers of intestinal disease progression.
HostingRepositoryPRIDE
AnnounceDate2024-09-16
AnnouncementXMLSubmission_2024-09-16_07:35:46.592.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRonja Rappold
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Salmonella enterica subsp. enterica; NCBI TaxID: NCBITaxon:59201;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-23 16:49:35ID requested
12024-09-16 07:35:46announced
Publication List
10.1111/FEBS.17120;
Keyword List
submitter keyword: LC-MSMS, Cecum,Mouse, Intestinal Edema
Contact List
Emma Slack
contact affiliationLaboratory for Mucosal Immunology, Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland
contact emailemma.slack@hest.ethz.ch
lab head
Ronja Rappold
contact affiliationETH Zurich
contact emailrrappold@ethz.ch
dataset submitter
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Dataset FTP location
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