PXD043256-1

PXD043256 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics analysis of Salmonella-infected mouse cecum
Description	The ECM is a complex fibrillar network of macromolecules that provides structural and mechanical support to the intestinal tissue. One abundant component of the ECM observed in the Salmonella-driven intestinal edema is the mechanosensitive glycoprotein fibronectin. Combining mechanosensitive staining for relaxed fibronectin with total fibronectin revealed that fibronectin fibers present in the edema are in a tensed molecular conformation. Co-staining with fibrin(ogen) indicates a provisional matrix, similar to what is observed in response to skin injury. The absence of low tensional fibronectin fibers and the additional finding of a high number of protease inhibitors in the edema proteome could indicate a critical role of stretched fibronectin fibers in maintaining tissue integrity in the severely inflamed cecum. Understanding these processes may provide valuable functional diagnostic markers of intestinal disease progression.
HostingRepository	PRIDE
AnnounceDate	2024-09-16
AnnouncementXML	Submission_2024-09-16_07:35:46.592.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ronja Rappold
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Salmonella enterica subsp. enterica; NCBI TaxID: NCBITaxon:59201;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-23 16:49:35	ID requested
⏵ 1	2024-09-16 07:35:46	announced

10.1111/FEBS.17120;

submitter keyword: LC-MSMS, Cecum,Mouse, Intestinal Edema

Emma Slack
contact affiliation	Laboratory for Mucosal Immunology, Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland
contact email	emma.slack@hest.ethz.ch
lab head
Ronja Rappold
contact affiliation	ETH Zurich
contact email	rrappold@ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD043256

PRIDE project URI

• PRIDE
  1. PXD043256
     1. Label: PRIDE project
     2. Name: Quantitative proteomics analysis of Salmonella-infected mouse cecum