PXD043238 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A SWI/SNF-dependent transcriptional repression mediated by POU2AF2/C11orf53 at enhancer. |
Description | Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), functions as a new co-activator of POU2F3, the master transcription factor which is critical for both normal and neoplastic tuft cell identity and viability. Here, we demonstrated that POU2AF2 functions as an “Yin-Yang” factor which mediates both transcriptional activation and repression at distal enhance elements. The proteomics study aims to identify potential interactors with POU2AF2 in different cell lines which may enable us to further understand the function of POU2AF2 in human cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-19 |
AnnouncementXML | Submission_2024-01-19_09:29:04.318.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lu Wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-23 06:25:21 | ID requested | |
⏵ 1 | 2024-01-19 09:29:04 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: co-activator,POU2AF2, SWI/SNF, small cell lung cancer |
Contact List
Lu Wang |
contact affiliation | Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. |
contact email | lu.wang1@northwestern.edu |
lab head | |
Lu Wang |
contact affiliation | Northwestern University |
contact email | lu.wang1@northwestern.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD043238 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043238
- Label: PRIDE project
- Name: A SWI/SNF-dependent transcriptional repression mediated by POU2AF2/C11orf53 at enhancer.