PXD043232-3

PXD043232 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry and phosphorylation analysis of ORC1 protein, wild type or RNA-binding mutant (R441A, R444A and R465A), in GAA-RNA (RNA interactors of ORC1 identified by RIP-seq and iCLIP) knockdown or control conditions.
Description	Mass spectrometry of wild type or mutant (RNA-binding) ORC1. Experiments were done in cellstransfected with a control ASO or an anti-GAA ASO, to knockdown RNA interactors of ORC1.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:12:19.645.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aina Maria Mas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-23 04:55:20	ID requested
1	2023-10-24 13:17:46	announced
2	2023-11-14 09:11:46	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:12:20	announced	2024-10-22: Updated project metadata.

10.1038/s41467-023-40105-3;

Mas AM, Go, ñ, i E, Ruiz de Los Mozos I, Arcas A, Statello L, Gonz, á, lez J, Bl, á, zquez L, Lee WTC, Gupta D, Sejas Á, Hoshina S, Armaos A, Tartaglia GG, Waga S, Ule J, Rothenberg E, G, ó, mez M, Huarte M, ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins. Nat Commun, 14(1):4447(2023) [pubmed]

submitter keyword: Phosphoproteomics of ORC1 with altered protein RNA-binding

Maite Huarte
contact affiliation	1 Center for Applied Medical Research, University of Navarra, Pio XII 55 Ave, 31008, Pamplona, Spain. 2 Institute of Health Research of Navarra (IdiSNA), Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
contact email	maitehuarte@unav.es
lab head
Aina Maria Mas
contact affiliation	Center for Applied Medical Research, University of Navarra, Pio XII 55 Ave, 31008, Pamplona, Spain
contact email	ammas@unav.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD043232

PRIDE project URI

• PRIDE
  1. PXD043232
     1. Label: PRIDE project
     2. Name: Mass spectrometry and phosphorylation analysis of ORC1 protein, wild type or RNA-binding mutant (R441A, R444A and R465A), in GAA-RNA (RNA interactors of ORC1 identified by RIP-seq and iCLIP) knockdown or control conditions.