PXD043192-1

PXD043192 is an original dataset announced via ProteomeXchange.

Title	Identification of TMEM106B-binding proteins in mouse brain
Description	TMEM106B is an endolysosomal transmembrane protein associated with many brain disorders, such as frontotemporal lobar degeneration, Alzheimer’s disease, and hypomyelinating leukodystrophy. In addition, recent cryo-EM studies have identified amyloid fibrils of carboxyl-terminal TMEM106B in the brains of those with neurodegeneration. However, so far little is known about precise functions of TMEM106B in the endolysosome and how the protein is involved in a great variety of human conditions at molecular levels. In this project, we sought to identify interaction partners of TMEM106B in the mouse brain by using immunoprecitation and liquid chromatography tandem mass spectrometry protein identification procedure.
HostingRepository	PRIDE
AnnounceDate	2024-08-06
AnnouncementXML	Submission_2024-08-06_01:04:50.025.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hideyuki Takahashi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-21 21:08:09	ID requested
⏵ 1	2024-08-06 01:04:50	announced

Dataset with its publication pending

submitter keyword: Mouse, Brain, Lysosome, LC-MS/MS

Stephen M. Strittmatter
contact affiliation	Department of Neuroscience, Yale University School of Medicine
contact email	stephen.strittmatter@yale.edu
lab head
Hideyuki Takahashi
contact affiliation	Yale University
contact email	hideyuki.takahashi@yale.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD043192

PRIDE project URI

• PRIDE
  1. PXD043192
     1. Label: PRIDE project
     2. Name: Identification of TMEM106B-binding proteins in mouse brain