PXD043192 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of TMEM106B-binding proteins in mouse brain |
Description | TMEM106B is an endolysosomal transmembrane protein associated with many brain disorders, such as frontotemporal lobar degeneration, Alzheimer’s disease, and hypomyelinating leukodystrophy. In addition, recent cryo-EM studies have identified amyloid fibrils of carboxyl-terminal TMEM106B in the brains of those with neurodegeneration. However, so far little is known about precise functions of TMEM106B in the endolysosome and how the protein is involved in a great variety of human conditions at molecular levels. In this project, we sought to identify interaction partners of TMEM106B in the mouse brain by using immunoprecitation and liquid chromatography tandem mass spectrometry protein identification procedure. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-06 |
AnnouncementXML | Submission_2024-08-06_01:04:50.025.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hideyuki Takahashi |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-21 21:08:09 | ID requested | |
⏵ 1 | 2024-08-06 01:04:50 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse, Brain, Lysosome, LC-MS/MS |
Contact List
Stephen M. Strittmatter |
contact affiliation | Department of Neuroscience, Yale University School of Medicine |
contact email | stephen.strittmatter@yale.edu |
lab head | |
Hideyuki Takahashi |
contact affiliation | Yale University |
contact email | hideyuki.takahashi@yale.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD043192 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043192
- Label: PRIDE project
- Name: Identification of TMEM106B-binding proteins in mouse brain