PXD043047-1

PXD043047 is an original dataset announced via ProteomeXchange.

Title	Therapeutic Effects of Valeriana jatamansi on Ulcerative Colitis: Insights into Mechanisms of Action through Metabolomics and Microbiome Analysis
Description	Ulcerative colitis (UC), belonging to inflammatory bowel disease (IBD), is a chronic and relapsing inflammatory disorders of the gastrointestinal tract, which is not completely cured so far. Valeriana jatamansi is a Chinese medicine used clinically to treat "diarrhea", which is closely related to UC. This study was to elucidate the therapeutic effects of V. jatamansi extract (VJE) on dextran sodium sulfate (DSS)-induced UC in mice and its underlying mechanism. In this work, VJE effectively ameliorate the symptoms, histopathological scores and reduce the production of inflammatory factors of UC mice. The colon untargeted metabolomics analysis and 16S rDNA sequencing showed remarkable differences in colon metabolite profiles and intestinal microbiome composition between the control and DSS groups, and VJE intervention can reduce these differences. Thirty-two biomarkers were found and modulated the primary pathways including pyrimidine metabolism, arginine biosynthesis and glutathione metabolism. Meanwhile, twelve significant taxa of gut microbiota were found. Moreover, there is a close relationship between endogenous metabolites and intestinal flora. These findings suggested that VJE ameliorates UC by inhibiting inflammatory factors, recovering intestinal maladjustment, and regulating the interaction between intestinal microbiota and host metabolites. Therefore, the intervention of V. jatamansi is a potential therapeutic treatment for UC.
HostingRepository	PRIDE
AnnounceDate	2023-07-24
AnnouncementXML	Submission_2023-07-24_02:13:46.441.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	lilxiawang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-16 00:33:20	ID requested
⏵ 1	2023-07-24 02:13:47	announced
2	2023-11-14 09:04:06	announced	2023-11-14: Updated project metadata.

Wang L, Zhang H, Tang F, Yan H, Feng W, Liu J, Wang Y, Tan Y, Chen H, on Ulcerative Colitis: Insights into Mechanisms of Action through Metabolomics and Microbiome Analysis. J Proteome Res, 22(8):2669-2682(2023) [pubmed]

submitter keyword: Valeriana jatamansi, metabolites, correlation analysis, ulcerative colitis, gut microbiota

YuzhuTan
contact affiliation	Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China
contact email	tanyuzhu@cdutcm.edu.cn
lab head
lilxiawang
contact affiliation	Chengdu University of Traditional Chinese Medicine
contact email	wanglixia@stu.cdutcm.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043047
     1. Label: PRIDE project
     2. Name: Therapeutic Effects of Valeriana jatamansi on Ulcerative Colitis: Insights into Mechanisms of Action through Metabolomics and Microbiome Analysis