PXD042908-2

PXD042908 is an original dataset announced via ProteomeXchange.

Title	Protein-protein interactions of p21 in MCF7 cells during cellular senescence
Description	A mass spectrometry-based proteomics analysis was performed to study the protein binders of p21 in MCF7 cells during the progression and maintenance of cellular senescence.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:43:31.742.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jia-Xuan Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-12 05:19:32	ID requested
1	2024-06-01 17:38:47	announced
⏵ 2	2024-10-22 06:43:32	announced	2024-10-22: Updated project metadata.

10.1093/nar/gkae426;

Schmidt A, Allmann S, Schwarzenbach C, Snyder P, Chen JX, Nagel G, Sch, ö, neis A, Rasenberger B, Beli P, Loewer A, Hofmann TG, Tomicic MT, Christmann M, The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence. Nucleic Acids Res, 52(12):6945-6963(2024) [pubmed]

submitter keyword: dimethyl-labelling, benzo[a]pyrene, senescence,protein-protein interactions, p21

Markus Christmann
contact affiliation	Institute of Toxicology, University Medical Center, Johannes Gutenberg University of Mainz
contact email	mchristm@uni-mainz.de
lab head
Jia-Xuan Chen
contact affiliation	Institute of Molecular Biology
contact email	j.chen@imb-mainz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD042908

PRIDE project URI

• PRIDE
  1. PXD042908
     1. Label: PRIDE project
     2. Name: Protein-protein interactions of p21 in MCF7 cells during cellular senescence