PXD042863-1

PXD042863 is an original dataset announced via ProteomeXchange.

Title	A microbial platform to produce recyclable plastics with customizable physical properties
Description	Plastics are one of the most important inventions of the modern era. Unfortunately, they are produced almost exclusively from non-renewable feedstocks (petroleum), and their recycling rates are extremely low, in part due to their chemical composition and the use of composite materials containing plastics that have very different deconstruction properties, making them virtually unrecyclable. Here, we describe the integration of computational, synthetic and polymer chemistry; synthetic biology; and life-cycle and technoeconomic analysis to design and produce highly recyclable plastics (biopolydiketoenimines, bioPDKs) that can be produced from renewable feedstocks and whose recycling properties can be tuned by the chemical substituents placed on one of the key bioPDK monomers, 𝛃-keto-𝛅-lactones (BKDLs). We engineered hybrid polyketide synthases to produce BKDLs with the various chemical substituents and stereochemistries that enable us to tune the conditions under which the resulting bioPDKs can be depolymerized, something that would be nearly impossible to do at scale using synthetic chemistry. These bioPDKs will enable recycling of some of the most difficult to recycle plastics, like composites.
HostingRepository	PRIDE
AnnounceDate	2026-05-26
AnnouncementXML	Submission_2026-05-25_16:58:31.338.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD042863
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christopher Petzold
SpeciesList	scientific name: Streptomyces albus subsp. albus; NCBI TaxID: NEWT:67257;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-09 13:38:10	ID requested
⏵ 1	2026-05-25 16:58:31	announced

10.6019/PXD042863;

submitter keyword: synthetic biology,Recyclable plastic, Biodegradable

Christopher J. Petzold
contact affiliation	Staff Scientist Biological Systems & Engineering Division Lawrence Berkeley National Laboratory Berkeley CA 94720
contact email	cjpetzold@lbl.gov
lab head
Christopher Petzold
contact affiliation	Lawrence Berkeley National Laboratory
contact email	cjpetzold@lbl.gov
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042863
     1. Label: PRIDE project
     2. Name: A microbial platform to produce recyclable plastics with customizable physical properties