PXD042860-1

PXD042860 is an original dataset announced via ProteomeXchange.

Title	Spatially differential regulation of ATF2 phosphorylation contributes to warning coloration of gregarious locusts
Description	Aposematism and warning coloration are common defense strategies used by animals to deter predators. Pestilential gregarious locusts display a striking black-brown pattern, which is presumed to be a form of warning coloration compared to green solitary locusts. However, the specific mechanisms involved in regulating this distinctive pattern are not yet understood. Here, we found that different amounts of β-carotene and β-carotene-binding protein (βCBP) complexes confer the black tergum and brown sternum of locust. The expression level of βCBP is regulated by the bZIP transcription factor ATF2, which is activated by protein kinase C alpha (PKCα) in response to crowding. Specifically, ATF2 is phosphorylated at Ser327 and translocates to the nucleus, where it binds to specific sites on the βCBP promoter and stimulates overexpression. Differential phosphorylation of ATF2 resulted in the divergent black and brown body coloration of gregarious locusts. The overexpression of βCBP in the sternum is essential for the accumulation of red pigments, which creates the sharp contrast between the black tergum and the brown sternum. This spatial variation in ATF2 phosphorylation levels allows locusts to adapt to changing environmental conditions and better evade predation.
HostingRepository	PRIDE
AnnounceDate	2023-08-24
AnnouncementXML	Submission_2023-08-23_21:25:50.706.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	XinleKang
SpeciesList	scientific name: Locusta migratoria manilensis; NCBI TaxID: 229990;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-09 13:31:19	ID requested
⏵ 1	2023-08-23 21:25:51	announced
2	2024-10-22 06:01:34	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: gregarious locusts,ATF2 phosphorylation, aposematic coloration, βCBP

XinleKang
contact affiliation	Beijing Institutes of Life Science, Chinese Academy of Sciences
contact email	kangxin_le@yeah.net
lab head
XinleKang
contact affiliation	Chinese Academy of Sciences
contact email	kangxin_le@yeah.net
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042860
     1. Label: PRIDE project
     2. Name: Spatially differential regulation of ATF2 phosphorylation contributes to warning coloration of gregarious locusts