PXD042810-1

PXD042810 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome
Description	The project aims to identify differentially expressed proteins that could be of biomarker value for patients with reversible cerebral vasoconstriction syndrome (RCVS). An RCVS-CSF spectral library resource was established from DDA/DIA analysis of cerebrospinal fluids of 21 RCVS patients and 20 sex-age-matched controls. Personalized RCVS-CSF proteomic profiles from patients and controls revealed alterations in the complement system, adhesion molecule, and extracellular matrix which might contribute to the disruption of the blood-brain barrier. The differentially expressed proteins within the patient cohorts, nominated potential biomarker candidates, and the protein signature suggested by machine learning techniques may provide insights into the unknown molecular understanding of the devastating disease.
HostingRepository	jPOST
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-13_08:00:06.805.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jhih-Ci Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-07 20:21:30	ID requested
⏵ 1	2025-10-13 08:00:07	announced

Publication List

Yang JC, Chen SP, Wang YF, Chang CH, Chang KH, Fuh JL, Chow LH, Han CL, Chen YJ, Wang SJ, Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome. Mol Cell Proteomics, 23(7):100794(2024) [pubmed]

Yang JC, Chen SP, Wang YF, Chang CH, Chang KH, Fuh JL, Chow LH, Han CL, Chen YJ, Wang SJ, Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome. Mol Cell Proteomics, 23(7):100794(2024) [pubmed]

Keyword List

submitter keyword: Reversible cerebral vasoconstriction syndrome (RCVS), Proteomics, Blood-brain barrier, Cerebrospinal fluid

submitter keyword: Reversible cerebral vasoconstriction syndrome (RCVS), Proteomics, Blood-brain barrier, Cerebrospinal fluid

Contact List

Yu-Ju Chen
lab head
Jhih-Ci Yang
contact affiliation	Institute of Chemistry, Academia Sinica, Taiwan
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002181/