PXD042792-2

PXD042792 is an original dataset announced via ProteomeXchange.

Title	Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation
Description	Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in understanding how the atlas of genomic aberrations in this cancer impacts the proteome and which somatic variants are of importance for the disease phenotype. We performed a quantitative proteomic analysis of 23 EACs and matched adjacent normal esophageal and gastric tissues. We explored the correlation of transcript and protein abundance using tissue-matched RNAseq and proteomic data from 7 patients and further integrated these data with a cohort of EAC RNA-seq data (n=264 patients), EAC whole-genome sequencing (n=454 patients) and external published datasets.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:54:29.468.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042792
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Javier Alfaro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-07 04:59:26	ID requested
1	2024-08-10 14:40:54	announced
⏵ 2	2024-10-22 06:54:35	announced	2024-10-22: Updated project metadata.

10.1016/j.mcpro.2024.100764;

10.6019/PXD042792;

submitter keyword: esophageal adenocarcinoma

Javier Alfaro
contact affiliation	International Center for Cancer Vaccine Science (ICCVS), University of Gdansk, Gdansk, Poland
contact email	javier.alfaro@proteogenomics.ca
lab head
Javier Alfaro
contact affiliation	University of Edinbuirgh
contact email	javier.alfaro@proteogenomics.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042792
     1. Label: PRIDE project
     2. Name: Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation