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PXD042725-1

PXD042725 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImpaired age-associated mitochondrial translation is mitigated by exercise and PGC-1alpha
DescriptionSarcopenia, the age-related loss of skeletal muscle mass and function, can dramatically impinge on quality of life and mortality. While mitochondrial dysfunction and imbalanced proteostasis are recognized as hallmarks of sarcopenia, the regulatory and functional link between these processes is underappreciated and unresolved. We therefore investigated how mitochondrial proteostasis, a crucial process that coordinates the expression of nuclear- and mitochondrial-encoded mitochondrial proteins with supercomplex formation and respiratory activity, is affected in skeletal muscle aging. Intriguingly, a robust mitochondrial translation impairment was observed in sarcopenic muscle, which is regulated by the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1alpha) with the estrogen-related receptor alpha (ERRalpha). Exercise, a potent inducer of PGC-1alpha activity, rectifies age-related reduction in mitochondrial translation, in conjunction with quality control pathways. These results highlight the importance of mitochondrial proteostasis in muscle aging, and elucidate regulatory interactions that underlie the powerful benefits of physical activity in this context.
HostingRepositoryMassIVE
AnnounceDate2023-08-07
AnnouncementXMLSubmission_2023-08-07_06:44:14.164.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdanilo ritz
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListTMTpro
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-05 02:04:49ID requested
12023-08-07 06:44:14announced
Publication List
no publication
Keyword List
submitter keyword: Sarcopenia, Mitochondria, Proteostasis, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Estrogen-Related Receptor alpha
Contact List
Alexander Schmidt
contact affiliationBiozentrum, Universtiy of Basel, 4056 Basel, Switzerland
contact emailalex.schmidt@unibas.ch
lab head
danilo ritz
contact affiliationUniversity of Basel
contact emaildanilo.ritz@unibas.ch
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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