PXD042575-1

PXD042575 is an original dataset announced via ProteomeXchange.

Title	Differential MAPK Phosphorylation of Connexin43
Description	MAPK family members are known to phosphorylate the c-terminal tail of connexin43 (cx43), however little is known about the preference of different MAPKs for specific cx43 phosphorylation sites. We utilized mass spectrometry to determine the cx43 sites phosphorylated in kinase assays by Erk, JNK, and p38.
HostingRepository	PRIDE
AnnounceDate	2025-01-14
AnnouncementXML	Submission_2025-01-14_09:08:39.690.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042575
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jason Conage-Pough
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-31 07:17:38	ID requested
⏵ 1	2025-01-14 09:08:40	announced

10.1016/j.jbc.2025.108178;

Latchford LP, Perez LS, Conage-Pough JE, Turk R, Cusimano MA, Vargas VI, Arora S, Shienvold SR, Kulp RR, Belverio HM, White FM, Th, é, venin AF, Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43. J Biol Chem, ():108178(2025) [pubmed]

10.6019/PXD042575;

submitter keyword: ERK, kinase assay,connexin43, p38, GJA1, JNK, MAPK

Forest Michael White
contact affiliation	Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
contact email	fwhite@mit.edu
lab head
Jason Conage-Pough
contact affiliation	MIT
contact email	jasoncp@mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD042575

PRIDE project URI

• PRIDE
  1. PXD042575
     1. Label: PRIDE project
     2. Name: Differential MAPK Phosphorylation of Connexin43