PXD042551-1

PXD042551 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular matrix orchestration of tissue remodelling during chronic colitis
Description	Ulcerative colitis is a debilitating and recurrent condition with significant co-morbidities including risk of developing cancer and that is associated with extensive tissue remodeling that is both a consequence and mediator of disease progression. Here, label-free mass spectrometry was used to characterise extracellular matrix remodelling in a murine model of colitis. Unique proteomic profiles of the extracellular matrix landscape distinguished inflamed from matched-normal colon tissue thus identifying pre- and pathological colitic states that were predominantly differentiated by expression of proteoglycans. Network maps derived from this dataset highlighted a central role for matrisomal proteins in epithelial-stromal interactions and identified orchestrating nodes that could be exploited in selection of therapeutic targets.
HostingRepository	MassIVE
AnnounceDate	2023-12-06
AnnouncementXML	Submission_2023-12-06_18:59:38.359.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joanna Bons
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-30 16:06:49	ID requested
⏵ 1	2023-12-06 18:59:38	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Inflammatory Bowel Diseases, Extracellular Matrix, Proteoglycans, Quantitative Proteomics, Data-Independent Acquisition (DIA)

submitter keyword: Inflammatory Bowel Diseases, Extracellular Matrix, Proteoglycans, Quantitative Proteomics, Data-Independent Acquisition (DIA)

Contact List

Birgit Schilling
contact affiliation	Buck Institute
contact email	bschilling@buckinstitute.org
lab head
Joanna Bons
contact affiliation	Buck Institute for Research on Aging
contact email	jbons@buckinstitute.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000092056/