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PXD042522-1

PXD042522 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A constant level of Pol III is maintained in the nucleus by nuclear retention and degradation-supplementery
Description	Pol III functions in the nucleus for transcription and cytoplasm as a viral-DNA sensor, but how cells maintain the cytoplasmic-to-nuclear partitioning of Pol III activity is unknown. Here, we found that Pol III forms transcription-dependent protein clusters in the nucleus and preferentially associates with assembly factors in the cytoplasm. Acute protein degradation of Pol III subunits followed by transient protein labeling showed that nuclear and cytoplasmic Pol III response differently after the loss of their subunits.
HostingRepository	iProX
AnnounceDate	2023-05-29
AnnouncementXML	Submission_2023-07-13_23:59:19.268.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-29 01:17:14	ID requested
⏵ 1	2023-07-13 23:59:19	announced
2	2024-05-29 21:54:15	announced	2024-05-30: Update information.

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Pol III, cytoplasm, nuclear

Contact List

Xiong Ji
contact affiliation	Peking University
contact email	xiongji@pku.edu.cn
lab head
Rui Wang
contact affiliation	Peking University
contact email	wyandpwl@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI