PXD042427 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Obatoclax rescues FUS-ALS phenotypes in iPSC-derived neurons by inducing autophagy |
Description | Disruption of protein homeostasis plays an essential role in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons is to de-repress autophagy by disrupting the inhibitory BECN1/BCL2 complex, which has been shown to improve healthspan and lifespan in mice. We screened small molecule BH3 mimetics using an induced pluripotent stem cell (iPSC)-based model of ALS with a FUS mutation and identified obatoclax rescued neurons at by reducing cytoplasmic FUS levels, restoring protein homeostasis, and reducing degeneration. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:31:27.622.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marc Gentzel |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-23 05:10:47 | ID requested | |
1 | 2023-10-16 03:55:43 | announced | |
⏵ 2 | 2023-11-14 08:31:27 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: DIA, Autophagy, iPSC-derived neurons, ALS, BH3 mimetic,Label-free Quantitative Mass Spectrometry, FUS |
Contact List
Prof. Dr. Jared Sterneckert |
contact affiliation | Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, Fetscherstraße 105, 01307, Dresden, Germany |
contact email | jared.sterneckert@tu-dresden.de |
lab head | |
Marc Gentzel |
contact affiliation | Molecular Analysis - Mass Spectrometry, Center for Molecular and Cellular Bioengineering (CMCB), TU Dresden |
contact email | marc.gentzel@tu-dresden.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042427 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042427
- Label: PRIDE project
- Name: Obatoclax rescues FUS-ALS phenotypes in iPSC-derived neurons by inducing autophagy