PXD042363-1

PXD042363 is an original dataset announced via ProteomeXchange.

Title	Cocaine-Induced Restructuring of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Expression
Description	Substance abuse, particularly cocaine, has detrimental effects on global public health, as acute intoxication often results in adverse outcomes and current pharmacological treatments exhibit limited effectiveness. The intricate process of cocaine intoxication involves substantial alterations in the brain's neurochemical systems, including fluctuations in neuropeptide levels. To unravel these complexities, we devised an acute intoxication model in rats and undertook a comprehensive brain peptidome analysis using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
HostingRepository	PRIDE
AnnounceDate	2025-01-03
AnnouncementXML	Submission_2025-01-02_16:24:04.790.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gaoyuan Lu
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-19 17:52:26	ID requested
⏵ 1	2025-01-02 16:24:05	announced

10.1021/ACSCHEMNEURO.4C00327;

submitter keyword: Rat, Brain, Peptidome, LC-MS/MS

Lingjun Li
contact affiliation	School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison
contact email	lingjun.li@wisc.edu
lab head
Gaoyuan Lu
contact affiliation	University of Wisconsin-Madison
contact email	gaoyuan.lu@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD042363

PRIDE project URI

• PRIDE
  1. PXD042363
     1. Label: PRIDE project
     2. Name: Cocaine-Induced Restructuring of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Expression