PXD042354-3

PXD042354 is an original dataset announced via ProteomeXchange.

Title	Aqueous and DMSO extracts from Annona muricata leaves protect from ferroptosis to both HT-1080 fibrosarcoma cells and HMEC-1 endothelial cells.
Description	Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed us to identify dozens of bioactive compounds. In the present study, we use a proteomic study to reveal new bioactivities of these leave extracts on both conditioned media and extracts of HT-1080 fibrosarcoma treated cells. Our results reveal the complete sets of deregulated proteins after treatment with aqueous and DMSO extracts from An-nona muricata leaves. Functional enrichment analysis of proteomic data suggests deregulation of cell cycle and iron metabolism, which are experimentally validated. Additional experimental data reveal that these extracts protect from ferroptosis to both HT-1080 fibrosarcoma cells and HMEC-1 endothelial cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:12:13.532.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Casimiro Cardenas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-18 23:47:18	ID requested
1	2023-10-24 13:15:46	announced
2	2023-11-14 09:11:42	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:12:14	announced	2024-10-22: Updated project metadata.

10.3390/ijms241512021;

Marrero AD, Quesada AR, Mart, í, nez-Poveda B, Medina M Á, C, á, rdenas C, Leaf Extracts in HT-1080 Fibrosarcoma Cells. Int J Mol Sci, 24(15):(2023) [pubmed]

submitter keyword: Proteomics,Annona muricata, Ferroptosis

Miguel Angel Medina
contact affiliation	Departament of Molecular Biologi and Biochemistry, Faculty of Sciences, University of Malaga, 29071 Malaga, Spain
contact email	medina@uma.es
lab head
Casimiro Cardenas
contact affiliation	University of Malaga
contact email	ccg@uma.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042354

PRIDE project URI

• PRIDE
  1. PXD042354
     1. Label: PRIDE project
     2. Name: Aqueous and DMSO extracts from Annona muricata leaves protect from ferroptosis to both HT-1080 fibrosarcoma cells and HMEC-1 endothelial cells.