PXD042229-2

PXD042229 is an original dataset announced via ProteomeXchange.

Title	Patient-based model systems for AD
Description	The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathogenesis in patient-based model systems including iPSC-derived brain cells transplanted into the mouse brain hippocampus, as well as human post-mortem hippocampal tissues. Our data showcase patient-based models to study the cellular origin, progression, and prion-like spread of AD pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:12:36.074.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Melinda Rezeli
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-15 05:12:31	ID requested
1	2023-10-24 14:00:34	announced
⏵ 2	2023-11-14 09:12:40	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:13:15	announced	2024-10-22: Updated project metadata.

Pomeshchik Y, Velasquez E, Gil J, Klementieva O, Gidl, ö, f R, Sydoff M, Bagnoli S, Nacmias B, Sorbi S, Westergren-Thorsson G, Gouras GK, Rezeli M, Roybon L, Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis. Acta Neuropathol Commun, 11(1):150(2023) [pubmed]

submitter keyword: hippocampus, hippocampal graft,Alzheimers disease

Melinda Rezeli
contact affiliation	Lund University BME
contact email	melinda.rezeli@bme.lth.se
lab head
Melinda Rezeli
contact affiliation	Lund University
contact email	melinda.rezeli@bme.lth.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042229

PRIDE project URI

• PRIDE
  1. PXD042229
     1. Label: PRIDE project
     2. Name: Patient-based model systems for AD