PXD042154-1

PXD042154 is an original dataset announced via ProteomeXchange.

Title	Blood RNAs predictive of molecular changes in the brain and clinical outcome in Parkinson’s disease
Description	The ability to use blood to predict the outcomes of Parkinson’s disease (PD), including disease progression and development of cognitive and motor complications, would be of enormous clinical value. We undertook deep RNA sequencing from the caudate and putamen of postmortem PD (n=35) and control (n=40) striatum, and compared molecular profiles with clinical features, and samples obtained from antemortem peripheral blood from an independent cohort. Cognitive and motor complications of PD were associated with molecular changes in the caudate (e.g., stress response) and putamen (endothelial pathways) respectively. Later and earlier-onset PD were molecularly distinct, and disease duration was associated with changes in caudate (oligodendrocyte development) and putamen (cellular senescence) respectively. Molecular signatures in the postmortem PD brain were also evident in antemortem peripheral blood, and correlated with clinical disease features. Together, these findings identify molecular signatures in PD patients' brain and blood of potential pathophysiologic and prognostic importance
HostingRepository	PRIDE
AnnounceDate	2023-07-05
AnnouncementXML	Submission_2023-07-05_11:01:12.101.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	SorenHeissel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-11 14:15:00	ID requested
⏵ 1	2023-07-05 11:01:12	announced
2	2023-11-14 07:03:28	announced	2023-11-14: Updated project metadata.

submitter keyword: Striatum,Parkinson’s disease

Robert B.Darnell
contact affiliation	Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10065
contact email	darnelr@rockefeller.edu
lab head
SorenHeissel
contact affiliation	Research Support Specialist
contact email	sheissel@rockefeller.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042154

PRIDE project URI

• PRIDE
  1. PXD042154
     1. Label: PRIDE project
     2. Name: Blood RNAs predictive of molecular changes in the brain and clinical outcome in Parkinson’s disease