PXD042133-1

PXD042133 is an original dataset announced via ProteomeXchange.

Title	Conus magus venom gland proteomics
Description	Marine cone snails have attracted researchers from all disciplines but early life stages have received limited attention due to difficulties accessing or rearing juvenile specimens. Here, we document the culture of Conus magus from eggs through metamorphosis to reveal dramatic shifts in predatory feeding behaviour between post-metamorphic juveniles and adult specimens. Adult C. magus capture fish using a set of paralytic venom peptides combined with a hooked radular tooth used to tether envenomed fish. In contrast, early juveniles feed exclusively on polychaete worms using a unique “sting-and-stalk” foraging behaviour facilitated by short, unbarbed radular teeth and a distinct venom repertoire that induces hypoactivity in prey. Our results demonstrate how coordinated morphological, behavioural and molecular changes facilitate the shift from worm- to fish-hunting in C. magus, and showcase juvenile cone snails as a rich and unexplored source of novel venom peptides for ecological, evolutionary and biodiscovery studies.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:39:34.905.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aymeric Rogalski
SpeciesList	scientific name: Conus magus; NCBI TaxID: 6492;
ModificationList	No PTMs are included in the dataset
Instrument	SCIEX instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-10 15:25:01	ID requested
⏵ 1	2024-10-08 11:39:35	announced

10.21203/RS.3.RS-2153130/V1;

submitter keyword: proteomics, mass spectrometry, LC-MS,Conus magus, MALDI-MS

Richard Lewis
contact affiliation	Institute for Molecular Bioscience - University of Queensland
contact email	r.lewis@uq.edu.au
lab head
Aymeric Rogalski
contact affiliation	University of Utah
contact email	aymeric.rogalski@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042133
     1. Label: PRIDE project
     2. Name: Conus magus venom gland proteomics