PXD042122-1

PXD042122 is an original dataset announced via ProteomeXchange.

Title	proteomic profiling of human meniscus
Description	There is a need to clarify the role of the meniscus in knee OA which may be aided by the identification of biomarkers that reflect the molecular events involved in the tissue degradation. This is of particular importance in the early stages of the degenerative processes, a crucial phase when it might still be possible to interfere with disease progression before tearing and critical loss of meniscal function occurs. One way to achieve this goal is exploratory proteomics by mass spectrometry (MS), which has the potential to analyse the proteome of complex samples. Thus, our aim was to gain new knowledge about the molecular processes within the human meniscus by comparing the proteomic profiles of both the lateral and medial meniscus from healthy controls, subjects with mild signs of joint degeneration, and patients with end-stage knee OA, using a non-targeted MS approach operating in data-independent acquisition (DIA) mode. For the research purpose six groups were established: medial and lateral menisci from control donors (n=12), medial and lateral menisci from donors with mild signs of joint degeneration (n=13) and medial and lateral menisci from end-stage knee OA patients (n=12).
HostingRepository	PRIDE
AnnounceDate	2024-04-03
AnnouncementXML	Submission_2024-04-03_06:24:55.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrik Onnerfjord
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-10 08:07:07	ID requested
⏵ 1	2024-04-03 06:24:56	announced
2	2024-04-12 03:04:19	announced	2024-04-12: Updated project metadata.
3	2024-10-22 06:35:02	announced	2024-10-22: Updated project metadata.

10.1016/J.OCARTO.2023.100417;

submitter keyword: osteoarthritis, meniscus,human

Patrik Onnerfjord
contact affiliation	Department of Clinical Sciences, Lund University, Sweden
contact email	patrik.onnerfjord@med.lu.se
lab head
Patrik Onnerfjord
contact affiliation	Lund University
contact email	patrik.onnerfjord@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD042122

PRIDE project URI

• PRIDE
  1. PXD042122
     1. Label: PRIDE project
     2. Name: proteomic profiling of human meniscus