PXD042077-3

PXD042077 is an original dataset announced via ProteomeXchange.

Title	Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications
Description	Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we established a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication. The integrated culture platform of a microfluidic chip and a three-dimensional heart extracellular matrix enhanced human cardiac tissue development and their structural and functional maturation. These tissues were comprised of cardiovascular lineage cells, including cardiomyocytes and cardiac fibroblasts derived from human induced pluripotent stem cells, as well as vascular endothelial cells. The resultant macroscale human cardiac tissues exhibited improved efficacy in drug testing (small molecules with various levels of arrhythmia risk), disease modeling (long QT syndrome and cardiac fibrosis), and regenerative therapy (myocardial infarction treatment). Therefore, our culture system can serve as a highly effective tissue-engineering platform to provide human cardiac tissues for versatile biomedical applications.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:28:28.990.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Sun Choi
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-08 22:29:24	ID requested
1	2024-02-02 22:50:14	announced
2	2024-02-07 03:53:08	announced	2024-02-07: Updated project metadata.
⏵ 3	2024-10-22 06:28:29	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Decellularization

Seung-Woo Cho
contact affiliation	Department of Biotechnology, Yonsei University, Republic of Korea
contact email	seungwoocho@yonsei.ac.kr
lab head
Yi Sun Choi
contact affiliation	Yonsei University
contact email	yisunchoi@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042077
     1. Label: PRIDE project
     2. Name: Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications